A second generation of steam-based sterilization systems (autoclave) with an integrated shredder has been developed and designed for on-site conversion of biohazard waste in health care facilities to be disposed as regular municipal waste, complying with the EU and WHO recommendations.Autoclaves technologies have been used for more than a century to sterilize medical instruments, and for the last several years they have been adapted for the treatment of infectious waste. ISS is also known as non-burn technology (non-incineration), so it does not cause air pollution, no harmful exhaust emissions and produce no ash residues (fly/bottom ash).The Integrated Sterilizer and Shredder (ISS) performs both shredding and waste steam sterilization in a single vessel is fitted with a motor-driven shaft, with powerful shredding blades which can rotate in two directions inside the vessel to reduce the size and volume of the waste down to 20% of the original volume.